Optimal Doses of Methotrexate Combined with Anti-TNF Therapy to Maintain Clinical Remission in Inflammatory Bowel Disease

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Optimal doses of methotrexate combined with anti-TNF therapy to maintain clinical remission in inflammatory bowel disease.

BACKGROUND AND AIMS Methotrexate (MTX) is sometimes used as part of combination therapy for the treatment of inflammatory bowel disease [IBD]; however, the optimal MTX dose for combination therapy has not been established. This study compared the efficacy of lower-dose and higher-dose MTX with anti tumor necrosis factor alpha (anti-TNF) therapy among IBD patients. METHODS Retrospective chart ...

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The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF wi...

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Crohn’s disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Although the primary etiological defect stil remains unknown, in the last decade impotant progress has been made concerning the immunological basis of the disease. Genetic, environmental and microbial factors result in repeated activation of mucosal immune response. Tumor necrosis factor alp...

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Probiotic yogurt Affects Pro- and Anti-inflammatory Factors in Patients with Inflammatory Bowel Disease

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Probiotic yogurt Affects Pro- and Anti-inflammatory Factors in Patients with Inflammatory Bowel Disease

     Inflammatory bowel disease (IBD) is an irregular response of immune system accompanied with different inflammatory manifestations including alterations in cytokines. Probiotics are non-pathogenic organisms with probable effects in various conditions such as inflammation. The present study hypothesized whether oral intake of bifidobacterium and lactobacillus in form of probiotic yogurt may ...

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ژورنال

عنوان ژورنال: Journal of Crohn's and Colitis

سال: 2015

ISSN: 1873-9946,1876-4479

DOI: 10.1093/ecco-jcc/jjv027